ProEn Therapeutics

No.	Year	Title	Journal
1	2021	Computationally-guided design and affinity improvement of a protein binder targeting a specific site on HER2	Computational and Structural Biotechnology Journal 2021 Feb 27;19:1325-1334
2	2020	Effective inhibition of C3a‐mediated pro‐inflammatory response by a human C3a‐specific protein binder	Biotechnology and Bioengineering 2020 Jun;117(6):1904-1908
3	2020	A regulatory SH2 domain-targeting protein binder effectively inhibits the activity of Bruton’s tyrosine kinase and its drug-resistant variant	Biochemical and Biophysical Research Communications 2020 May 21;526(1):8-13
4	2019	Computer-aided Binding Mode Prediction and Affinity Maturation of LRR Protein 2 Binder without Structural Determination	PLOS Computational Biology 2020 Aug 31;16(8):e1008150
5	2020	A small-sized protein binder specific for human PD-1 effectively suppresses the tumor growth in tumor mouse model	Journal of Drug Targeting 2020 Apr;28(4):419-427
6	2019	Prolonged half-life of small-sized therapeutic protein using serum albuminspecific protein binder	Journal of Controlled Release 2019 Dec 10;315:31-39
7	2018	Engineering and cytosolic delivery of a native regulatory protein and its variants for modulation of ERK2 signaling pathway	Biotechnology and Bioengineering 2018 Apr;115(4):839-849
8	2017	Intracellular protein delivery system using a target-specific repebody and translocation domain of bacterial exotoxin	ACS Chemical Biology 2017 Nov 17;12(11):2891-2897
9	2017	A High-Affinity Repebody for Molecular Imaging of EGFR-Expressing Malignant Tumors	Theranostics 2017 Jun 25;7(10):2620-2633
10	2016	Effective suppression of C5a-induced proinflammatory response using anti-human C5a repebody	Biochemical and Biophysical Research Communications 2016 Sep 2;477(4):1072-1077
11	2016	Engineering of bacterial exotoxins for highly efficient and receptor-specific intracellular delivery of diverse cargos	Biotechnology and Bioengineering 2016 Aug;113(8):1639-46
12	2016	Anti-Human VEGF Repebody Effectively Suppresses Choroidal Neovascularization and Vascular Leakage	PLOS one 2016 Mar 25;11(3):e0152522
13	2015	Enzymatic Prenylation and Oxime Ligation for the Synthesis of Stable and Homogeneous Protein–Drug Conjugates for Targeted Therapy	Angewandte Chemie 2015 Oct 5;54(41):12020-4
14	2014	A high-affinity protein binder that blocks the IL-6/STAT3 signaling pathway effectively suppresses non-small cell lung cancer	Molecular Therapy 2014 Jul;22(7):1254-1265
15	2014	Protein Binder for Affinity Purification of Human Immunoglobulin Antibodies	Analytical Chemistry 2014 Jun 17;86(12):6019-25
16	2012	Design of a binding scaffold based on variable lymphocyte receptors of jawless vertebrates by module engineering	PNAS 2012 Feb 28;109(9):3299-304

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